Given the (extreme) level of technicality involved in all of this, and the fact that it generally requires a combined understanding of graduate level physics, physiology, and psychology, it is not so surprising that these higher and more exotic/abstract levels of optimization have been heretofore omitted--let alone have any presence in the popular awareness (hence the apparent reasonableness of the question). Fortunately, Magic-Flight's lead designer does happen to have this level of knowledge, and since they are all true geeks, they tend to go for this sort of thing. Magic-Flight has found that when implemented, such optimizations do make a difference, as user experience is able to attest. Magic-Flight figures that the overall magnitude of these second, third, and forth order effects is about 30%. The effort involved to get that additional yield, however, is at least 30X over that of the heating system design, and tends to require someone who has taken about 20 or so years of advanced schooling.
The structure of cyclocreatine is fairly flat (planar), which aids in passive diffusion across membranes. It has been used with success in an animal study, where mice suffered from a SLC6A8 (creatine transporter at the blood brain barrier) deficiency, which is not responsive to standard creatine supplementation.  This study failed to report increases in creatine stores in the brain, but noted a reduction of mental retardation associated with increased cyclocreatine and phosphorylated cyclocreatine storages.  As demonstrated by this animal study and previous ones, cyclocreatine is bioactive after oral ingestion   and may merely be a creatine mimetic, able to phosphorylate ADP via the creatine kinase system.