Ashkenazi et al (2010) stated that interventional procedures such as PNBs and trigger point injections (TPIs) have long been used in the treatment of various headache disorders. There are, however, little data on their effectiveness for the treatment of specific headache syndromes. Moreover, there is no widely accepted agreement among headache specialists as to the optimal technique of injection, type, and doses of the local anesthetics used, and injection regimens. The role of corticosteroids in this setting is also being debated. These investigators performed a PubMed search of the literature to find studies on PNBs and TPIs for the treatment of headaches. They classified the abstracted studies based on the procedure performed and the treated condition. These researchers found few controlled studies on the effectiveness of PNBs for headaches, and virtually none on the use of TPIs for this indication. The most widely examined procedure in this setting was greater occipital nerve block, with the majority of studies being small and non-controlled. The techniques, as well as the type and doses of local anesthetics used for PNBs, varied greatly among studies. The specific conditions treated also varied, and included both primary (., migraine, cluster headache) and secondary (., cervicogenic, post-traumatic) headache disorders. Trigeminal (., supraorbital) nerve blocks were used in few studies. Results were generally positive, but should be taken with reservation given the methodological limitations of the available studies. The procedures were generally well-tolerated. The authors concluded that there is a need to perform more rigorous clinical trials to clarify the role of PNBs and TPIs in the management of various headache disorders, and to aim at standardizing the techniques used for the various procedures in this setting.
My problem with Tren for bulking is that bulking is a long process, usually 3-5 months for me, as I slow bulk. Also I need to eat way above maintenance. Tren gives me terrible acid reflux, runny stool, sleep issues, an the sides become stronger as times goes on. So for Tren I can run it about 8 weeks before I need to drop the compound. Bulking on NPP, I get zero sides, could run it for years straight if the bloods didn't eventually get whacked. Some people get zero sides from Tren and can bulk incredibly well as I understand it. But for me that's not the case. I could add a very low dose to my current 500:500:350 Test:Tren:Mast cycle, but then I'm mixing two 19-Nor, would need to increase Caber, and I just wouldn't see the benefits. So I use Tren for cutting. I eat less on a cut, and Tren helps with that as I don't feel like eating as much anyhow. Being the strongest AAS, it helps me retain muscle mass even on a huge deficit with DNP. Low doses are effective for retaining muscle mass, so the sides don't kill me. My go-to cycle is turning out to be 4 months bulk, 500:500:350 Test:NPP:Mast, then two months (or less) cut at 250:350:350 Test:Tren:Mast. (Test-E, all other are short compounds). Oh, one last thing, I get much less sides on low test with Tren than running mid-high test with Tren. 250:350 Test:Tren is almost side's free (except I need a lot of Zantac) whereas 500:350 Test:Tren gets me anxiety and sleep issues along with the regular acid reflux. Hope this helps. Remember everyone is different - you may be one of the lucky ones who's body loves tren and complains not.
Equipoise can produce androgenic side effects such as acne, accelerated hair loss in those predisposed to male pattern baldness and body hair growth. However, the overall androgenicity of this steroid is greatly reduced due to the structural nature that creates EQ in its double bond at the carbon one and two position. Such side effects of Equipoise are still possible, but they will be strongly linked to genetic predisposition, but most will find the threshold is fairly high.
When combating the possible androgenic side effects of Equipoise, it’s important to note they are brought on by the steroid being metabolized by the 5-alpha reductase enzyme. This metabolism will reduce Boldenone to an extremely potent androgen in dihydroboldenone, far more potent than dihydrotestosterone (DHT); however, the total dihydroboldenone activity has proven to be extremely low in human beings. You will further find the androgenic nature of Boldenone will not be significantly affected by 5-alpha reductase inhibitors like Finasteride that are often used to combat the reduction to DHT.
Due to the androgenic nature of Equipoise, women may potentially experience virilization symptoms. Virilization symptoms may include body hair growth, a deepening of the vocal chords and clitoral enlargement. However, the low androgenicity will make this steroid possible to use for some women without such symptoms. At the same time, the extremely slow acting nature of the compound can make it difficult to control regarding blood levels, and alternative steroids may be preferred. Without question, individual sensitivity will dictate a lot. If Equipoise is used and virilization symptoms begin to show, use should be discontinued immediately at their onset and they will fade away. If symptoms begin to show and are ignored, the symptoms may become irreversible.