Male sex hormones

Hypogonadism, infertility, and sexual dysfunction occur in some men with coeliac disease. We have measured plasma testosterone, dihydrotestosterone, sex-hormone binding globulin, oestradiol, and serum luteinising hormone in 41 men with coeliac disease and have related these findings to jejunal morphology, fertility, semen quality, and sexual function. To determine the specificity of these observations in coeliacs we also studied 19 nutritionally-matched men with Crohn's disease, and men with chronic ill-health due to rheumatoid arthritis and Hodgkin's disease. The most striking endocrine findings in untreated coeliacs were increased plasma testosterone and free testosterone index, reduced dihydrotestosterone (testosterone's potent peripheral metabolite), and raised serum luteinising hormone, a pattern of abnormalities indicative of androgen resistance. As jejunal morphology improved hormone levels appeared to return to normal. This specific combination of abnormalities was not present in any of the disease control groups and, to our knowledge, androgen resistance has not been described previously in any other non-endocrine disorder. Plasma oestradiol concentration was modestly raised in 10% of coeliacs and 11% of patients with Crohn's disease. Unlike plasma androgens and serum luteinising hormone in coeliacs, plasma oestradiol was not clearly related to jejunal morphology. Androgen resistance and associated hypothalamic-pituitary dysfunction appear to be relatively specific to coeliac disease and cannot be explained merely in terms of malnutrition or chronic ill-health. In addition, our findings suggest that this endocrine disturbance may be related to sexual dysfunction in coeliac disease but its relationship to disordered spermatogenesis in this condition has not been clearly established.

Androgens, the male sex hormones, play an essential role in male sexual differentiation and development. However, the influence of these sex hormones extends beyond their roles in sexual differentiation and development. In many animal species, sex hormones have been shown to be essential for sexual differentiation of the brain during development and for maintaining sexually dimorphic behavior throughout life. The principals of sex determination in humans have been demonstrated to be similar to other mammals. However, the hormonal influence on sexual dimorphic differences in the nervous system in humans, sex differences in behaviors, and its correlations with those of other mammals is still an emerging field. In this review, the roles of androgens in gender and cognitive function are discussed with the emphasis on subjects with androgen action defects including complete androgen insensitivity due to androgen receptor mutations and 5alpha-reductase-2 deficiency syndromes due to 5alpha-reductase-2 gene mutations. The issue of the complex interaction of nature versus nurture is addressed.

BIOIDENTICAL HORMONE REPLACEMENT Millions of women today experience some kind of health issue relating to their hormones, ranging from premenstrual moodiness or sugar cravings, to severe hot flashes and sleep problems during menopause. Infertility and miscarriages are becoming more and more common. And while more and more women are searching for solutions, frequently the only solution offered to them by their doctors is to put artificial hormones into their body to relieve their symptoms. Hence the millions of prescriptions for […]
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Millions of women today experience some kind of health issue relating to their hormones, ranging from premenstrual moodiness or sugar cravings, to severe hot flashes and sleep problems during menopause. Infertility and miscarriages are becoming more and more common. And while more and more women are searching for solutions, frequently the only solution offered to them by their doctors is to put artificial hormones into their body to relieve their symptoms. Hence the millions of prescriptions for synthetic Hormone Replacement […]
[Continue Reading]

Male sex hormones

male sex hormones

Millions of women today experience some kind of health issue relating to their hormones, ranging from premenstrual moodiness or sugar cravings, to severe hot flashes and sleep problems during menopause. Infertility and miscarriages are becoming more and more common. And while more and more women are searching for solutions, frequently the only solution offered to them by their doctors is to put artificial hormones into their body to relieve their symptoms. Hence the millions of prescriptions for synthetic Hormone Replacement […]
[Continue Reading]

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