Nandrolone phenylpropionate detection time

Nandrolon , auch 19-Nortestosteron, ist ein anaboles Steroid . Es beeinflusst wie Testosteron die Entwicklung der männlichen Geschlechtsorgane und den Eiweißaufbau in der Muskulatur . Beim durchschnittlichen Mann ist das Verhältnis im Körper von Testosteron zu Nandrolon 50:1. Da Nandrolon eine wesentlich höhere Aktivität als Testosteron aufweist und das Verhältnis zwischen virilisierender Wirkung und anaboler Wirkung zugunsten des Stoffwechseleffekts verschoben ist, ist es als Dopingmittel von größerem Interesse. Trenbolon ist ein Abkömmling des Nandrolon. Nandrolon wird im Organismus aus Testosteron durch Oxidation der Methylgruppe in Position 10 und anschließender Retro- Claisen-Umlagerung synthetisiert.

Using a randomized "double-blind" "placebo-controlled" design, 16 experienced male bodybuilders (age: 19-44 yr) either received ND (200 (-1), intramuscularly) or placebo for 8 wk. Body composition was assessed using the four-component model, combining results from underwater weighing, dual-energy x-ray absorptiometry (DXA), and deuterium dilution. Total bone mineral content and density were measured using DXA. Water compartments (extracellular water [ECW] and intracellular water [ICW]) were determined using deuterium dilution and bromide dilution.

Nandrolone decanoate (Deca-Durabolin) was injected intramuscularly into healthy volunteers. One group of females received one injection of 100 mg and three groups of males received one injection of 200 mg, two repeat injections of 100 mg or four repeat injections of 50 mg respectively. The serum levels of nandrolone (19-nortestosterone) were determined by radioimmunoassay and used to estimate pharmacokinetic parameters. The following pharmacokinetic parameters were found: a mean half-life of 6 days for the release of the ester from the muscular injection depot into the general circulation; a mean half-life of h for the combined processes of hydrolysis of nandrolone decanoate and of distribution and elimination of nandrolone; a mean nandrolone serum clearance of 1 X h-1 X kg-1. The half-life of hydrolysis of nandrolone decanoate in serum was of the order of one hour or less. The data are consistent with linear kinetics.

Nandrolone phenylpropionate detection time

nandrolone phenylpropionate detection time

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