A search of the FDA Adverse Event Reporting System (FAERS) database from November 1997 to May 2015, identified 178 . cases of apparently healthy patients who took an oral fluoroquinolone to treat ABS, ABECB, or uncomplicated UTIs and developed disabling and potentially irreversible adverse reactions that appeared as a constellation of symptoms. Because it was difficult to clearly ascertain whether the report was for treatment of two of these indications, ABECB or uncomplicated UTI, the search was broadened to include the indications “bronchitis” and “urinary tract infections” in addition to ABS, ABECB, and uncomplicated UTI. Only patients who reported adverse reactions lasting longer than a month and involving two or more body systems (., musculoskeletal, peripheral nervous system, neuropsychiatric, senses, cardiovascular, and skin) were included in the evaluation. The majority of the adverse reactions primarily affected the musculoskeletal system, peripheral nervous system, and central nervous system.