Testosterone for older men

As soon as the DSMB made its recommendation, the treatment phase of the trial was halted. All participants were promptly notified and asked to meet with study physicians to discuss any questions they might have. The men who experienced cardiovascular events were treated by their personal physicians for their specific conditions. No new participants will be enrolled in the study. The study team will continue to monitor the health of all participants for at least another year after stopping testosterone use to further evaluate effects of the treatment.

“The trials’ results indicate that, for older men with low sexual function, testosterone treatment can contribute to improved function,” said Evan Hadley, ., director of NIA’s Division of Geriatrics and Clinical Gerontology. “In contrast, though, the results don’t indicate that testosterone treatment for older men with low walking ability or vitality will improve these conditions to a great extent. Additional trial arms tested effects on other aging-related outcomes, and we are looking forward to their results to help provide further insights into testosterone use in older men.” Older men should consult their physicians if considering a testosterone treatment, Hadley emphasized.

Maybe. If you’re a man, that is, suffering from true hypogonadism (insufficient testosterone production) as a result of genetics, injury, or infection. USADA constantly shoos away male TUE applicants who claim testosterone deficiencies but who are at best borderline “low” in testosterone. That perhaps earns them a prescription for voguish, supplemental “T” from their doctors, but not a hall pass to enter races. As VeloNews recently reported, USADA has even granted a special Recreational Competitor Therapeutic Use Exemption (RCTUE) for supplemental testosterone to a couple of aging male athletes. The unusual TUE is in effect so long as those guys don’t win.

The TOM study is the first, single-site, placebo-controlled, randomized clinical trial designed to comprehensively determine the effects of testosterone administration on muscle strength and physical function in older men with mobility limitations. A total of 252 community dwelling individuals aged 65 and older with low testosterone levels and self-reported limitations in mobility and short physical performance battery (SPPB) scores between 4 and 9 will be randomized to receive either placebo or testosterone therapy for 6 months. The primary objective is to determine whether testosterone therapy improves maximal voluntary muscle strength as quantified by the one repetition maximum. Secondary outcomes will include measures of physical function (walking, stair climbing and a lifting and lowering task), habitual physical activity and self-reported disability. The effects of testosterone on affect, fatigue and sense of well being will also be assessed. Unique aspects of the TOM Trial include selection of men with self-reported as well as objectively demonstrable functional limitations, community-based screening and recruitment, adjustment of testosterone dose to ensure serum testosterone levels in the target range while maintaining blinding, and inclusion of a range of self-reported and performance-based physical function measures as outcomes. identifier: NCT00240981 .

Testosterone for older men

testosterone for older men

The TOM study is the first, single-site, placebo-controlled, randomized clinical trial designed to comprehensively determine the effects of testosterone administration on muscle strength and physical function in older men with mobility limitations. A total of 252 community dwelling individuals aged 65 and older with low testosterone levels and self-reported limitations in mobility and short physical performance battery (SPPB) scores between 4 and 9 will be randomized to receive either placebo or testosterone therapy for 6 months. The primary objective is to determine whether testosterone therapy improves maximal voluntary muscle strength as quantified by the one repetition maximum. Secondary outcomes will include measures of physical function (walking, stair climbing and a lifting and lowering task), habitual physical activity and self-reported disability. The effects of testosterone on affect, fatigue and sense of well being will also be assessed. Unique aspects of the TOM Trial include selection of men with self-reported as well as objectively demonstrable functional limitations, community-based screening and recruitment, adjustment of testosterone dose to ensure serum testosterone levels in the target range while maintaining blinding, and inclusion of a range of self-reported and performance-based physical function measures as outcomes. identifier: NCT00240981 .

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