Undecylenic acid oral side effects

Nonprescription agents have also been used for treatment of onychomycosis ( Table 4 ) . 31 , 33 – 38 These therapies have been evaluated in only a small number of studies involving few patients. Topical mentholated ointment (Vicks Vaporub) was used in a small study involving 18 patients. 37 After 48 weeks, 28% had mycotic and clinical cure, 56% had partial clearance, and 17% had no improvement. Tea tree oil ( Melaleuca alternifolia ) has been evaluated in two studies. Although one trial was favorable, combined data from both studies did not demonstrate significant benefit. 29 , 36 Snakeroot extract ( Ageratina pichinchensis ) is an antifungal derived from plants of the sunflower family. It was studied in a randomized trial involving 96 patients who applied the extract or ciclopirox for six months to nails with confirmed infections. 33 Mycotic cure occurred in 59% of patients receiving the extract and in 64% of those receiving ciclopirox. Clinical cure occurred in 71% and 81% of patients, respectively. Differences between the two treatments were not statistically significant. A small study showed that a combination of cyanoacrylate, undecylenic acid, and hydroquinone (marketed as Renewed Nail) demonstrated mycotic cure in 78 of 154 participants (50%). 34

There are also many drug interactions . Patients must read in detail the enclosed data sheet(s) of the medicine. For example, the azole antifungals such as ketoconazole or itraconazole can be both substrates and inhibitors of the P-glycoprotein , which (among other functions) excretes toxins and drugs into the intestines. [20] Azole antifungals also are both substrates and inhibitors of the cytochrome P450 family CYP3A4 , [20] causing increased concentration when administering, for example, calcium channel blockers , immunosuppressants , chemotherapeutic drugs , benzodiazepines , tricyclic antidepressants , macrolides and SSRIs .

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Ingredients : De-ionized Water, Aloe Vera (Aloe barbadensis) Leaf Gel*, Emulsifying Wax, Avocado Oil (Persea gratissima), Vegetable Glycerin, Stearic Acid (vegetable source), Natural Progesterone (USP Grade), Phospholipids (from Soy Lecithin), Glucose/Glucose Oxidase/Lactoperoxidase (natural preservative), Balancing Herbal Blend of: Rosemary Leaf Extract (Rosmarinus officinalis), Grapefruit Seed Extract (Citrus grandis), Carrot Oil (Daucua carota sativa), Sarsaparilla Root Extract (Smilax officinalis syn. S. regelii), Dong Quai Root Extract (Angelica polymorpha var. sinensis), Saw Palmetto Extract (Serenoa serrulata Fruit Extract), Chamomile Flower Extract (Matricaria recutita), Lemongrass Oil (Cymbopogon citratus) and Comfrey Root Extract (Symphytum officinale), Triethanolamine, Carbomer, Natural Vitamin E (as d-alpha-Tocopherol), Potassium Sorbate, Panthenol, Vitamin A (as Retinyl Palmitate), Citric Acid and Xanthan Gum (Xanthomonas campestris). *Certified Organic  

Undecylenic acid oral side effects

undecylenic acid oral side effects

Ingredients : De-ionized Water, Aloe Vera (Aloe barbadensis) Leaf Gel*, Emulsifying Wax, Avocado Oil (Persea gratissima), Vegetable Glycerin, Stearic Acid (vegetable source), Natural Progesterone (USP Grade), Phospholipids (from Soy Lecithin), Glucose/Glucose Oxidase/Lactoperoxidase (natural preservative), Balancing Herbal Blend of: Rosemary Leaf Extract (Rosmarinus officinalis), Grapefruit Seed Extract (Citrus grandis), Carrot Oil (Daucua carota sativa), Sarsaparilla Root Extract (Smilax officinalis syn. S. regelii), Dong Quai Root Extract (Angelica polymorpha var. sinensis), Saw Palmetto Extract (Serenoa serrulata Fruit Extract), Chamomile Flower Extract (Matricaria recutita), Lemongrass Oil (Cymbopogon citratus) and Comfrey Root Extract (Symphytum officinale), Triethanolamine, Carbomer, Natural Vitamin E (as d-alpha-Tocopherol), Potassium Sorbate, Panthenol, Vitamin A (as Retinyl Palmitate), Citric Acid and Xanthan Gum (Xanthomonas campestris). *Certified Organic  

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